In summary, in vitro studies have demonstrated that fatty acids induce tight junction formation in brain capillary ECs. On the other hand, brain endothelial cells take up preformed PUFA and transfer them into the brain. Furthermore, astro-cytes can complete the conversion of precursors to DHA and arachidonic acid. Astrocytes may modulate tight junctions through provision of fatty acids.
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Yamagata, K., Tagami, M., Takenaga, F., Yamori, Y., Nara, Y., and Itoh, S.
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Dr. Yamagata is at the Laboratory of Preventive Nutrition, Department of Food Science and Technology College of Bioresource Sciences, Nihon University. His current research includes control of tight junctions and brain and nutrients.
Dr. Tagami is at the Department of Internal Medicine, Sanraku Hospital. He is studying the pathology of stroke.
Dr. Nara is with the Laboratory of Health Science, Department of Biological Pharmacy, School of Pharmacy, Shujitu University.
Dr. Itoh is at the Laboratory of Food Science, Department of Food Science and Technology College of Bioresource Sciences, Nihon University. He is studying fatty acids analysis and brain nutritional relation.
Dr. Yamori is with the World Health Organization Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases studying preventive nutrition and food.
Dr. Yokogoshi is with the Laboratory of Nutritional Biochemistry, School of Food and Nutritional Sciences, The University of Shizuoka, and his current research is Nutritional Biochemistry.
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