Complement Deficiency States

Spontaneous complement deficiencies give us clues to the biological functions of complement in humans (Table 2). Deficiency of C3 produces a predisposition to bacterial infection that can be lethal. Such patients also display a deficient repertoire of antibodies, possibly due to a lack of CR2-mediated lymphocyte events in the absence of C3b-mediated opsonization of new antigens. C3 deficiency occurs in several different ways: a genetic lack of C3 production, a secondary loss due to accelerated fluid-phase cleavage from an inborn deficiency of factor 1 or factor H, or acquisition of an autoantibody that causes C3 activation. Excess bacterial infections are seen in patients with granu-locyte deficiencies of CR3 and other adhesion molecules or with deficiencies of properdin. Immune complex diseases result from deficiencies of erythrocyte CR1 expression or of classical pathway proteins, as (in primates) the classical pathway produces immune complex clearance. Patients deficient in C8 or C9 display increased susceptibility to infection by Neisseria bacterial species.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook


Post a comment