This disease is usually associated with atrophy of the exocrine parts of the pancreas as well as histological changes in the vasculature, and the blood flow to the whole pancreas is decreased . At present the exact role of pancreatic ischemia as an initiator or perpetuator of the disease is unclear, as is the extent to which the blood flow regulation during these conditions is altered.
Islet blood flow has so far been investigated only acutely after duct ligation, which leads to atrophy of the exocrine pancreas and growth and neogenesis of islets. However, up to 4 weeks after ligation islet blood flow remains normal, despite the fact that the total islet volume increases.
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