Chemokines Released by LECs and BECs

LECs and BECs express several chemokines that modulate leukocyte adhesion, migration, and inflammation. LECs apparently release several CXC, CC, and C chemokines. LECs express mRNAs for KC, IP10, Mig-1, BCL, MIP-2, SLC, RANTES, MCP-1, C10, and Lptn, but not MIP-1a,b or g. The release of C-10 is especially unusual for LEC since C-10 expression had long been thought to be limited to cells of the hematopoietic lineage. LECs, but not BECs, constitutively secrete the CC chemokine receptor CCR-7 ligand secondary lymph node-associated chemokine (SLC)/ CCL21 at their basolateral surface, and secretion is suppressed by TNF-a and IL-1p.

Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

Get My Free Ebook


Post a comment