LECs and BECs express several chemokines that modulate leukocyte adhesion, migration, and inflammation. LECs apparently release several CXC, CC, and C chemokines. LECs express mRNAs for KC, IP10, Mig-1, BCL, MIP-2, SLC, RANTES, MCP-1, C10, and Lptn, but not MIP-1a,b or g. The release of C-10 is especially unusual for LEC since C-10 expression had long been thought to be limited to cells of the hematopoietic lineage. LECs, but not BECs, constitutively secrete the CC chemokine receptor CCR-7 ligand secondary lymph node-associated chemokine (SLC)/ CCL21 at their basolateral surface, and secretion is suppressed by TNF-a and IL-1p.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.