Chemokines Released by LECs and BECs

LECs and BECs express several chemokines that modulate leukocyte adhesion, migration, and inflammation. LECs apparently release several CXC, CC, and C chemokines. LECs express mRNAs for KC, IP10, Mig-1, BCL, MIP-2, SLC, RANTES, MCP-1, C10, and Lptn, but not MIP-1a,b or g. The release of C-10 is especially unusual for LEC since C-10 expression had long been thought to be limited to cells of the hematopoietic lineage. LECs, but not BECs, constitutively secrete the CC chemokine receptor CCR-7 ligand secondary lymph node-associated chemokine (SLC)/ CCL21 at their basolateral surface, and secretion is suppressed by TNF-a and IL-1p.

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