Antiangiogenic Factors

Angiogenesis is under tight negative control and factors are expressed that limit neovascularization in a wound healing or hypoxic response. First, oxygenation status is a powerful determinant. Hyperoxia is a potent inhibitor of EC proliferation, angiogenesis, and the expression of key growth factors including VEGF. Inhibitors of angiogenesis include angiostatin, endostatin, interferon-a/p/g, inter-leukins, platelet factor 4, thrombospondin-1, TIMP, and TNF-a. Some MMPs also act as inhibitors. MMP-1 and MMP-3 interfere with integrin binding and MMP-7 and -9 generate angiostatin from plasminogen, thereby inhibiting EC proliferation. Apoptosis of ECs appears to be a key event that mediates the cessation of angiogenesis.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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