Angiostatin is a 38-kDa protein, derived from an internal fragment of plasminogen spanning the first four kringle domains that. Kringles 1-3 of plasminogen also exhibit antiangiogenic activity. The conversion of plasminogen to angiostatin appears to require reduction of disulfide bonds followed by proteolysis with one or more proteinases. Angiostatin was originally purified from the urine of mice with Lewis lung carcinoma and is generated endogenously by a variety of human tumors as well. Angiostatin inhibits neovascularization in the mouse corneal angiogenesis assay and in the chick chorioallantoic membrane assay. Angio-statin inhibits the growth of primary tumors and metastases in mice and induces complete regression of human tumors implants in nude mice.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.