AM Receptors in the Cerebral Microcirculation

The fact that AM behaves as a local autocrine and/or paracrine hormone raises the possibility that AM released by CECs acts primarily on AM receptors present in the cerebral endothelium itself and on neighboring cells. The expression of CRLR, RAMP-1, -2, -3, was characterized on isolated rat cerebral microvessels [4], in rat CECs and cerebral pericytes [3], and in rat astrocytes [2]. In cultured rat CECs and peri-cytes RAMP-2 showed the highest expression, followed by RAMP-3 and RAMP-1, and exogenous AM increased the intracellular cAMP concentration suggesting the existence of functional AM receptors on these cells [3]. Although astrocyte-derived factors increased the AM production of rat CECs, they did not change the expression of AM receptor components in rat CECs. Oliver et al. [5] reported the same expression pattern of RAMPs in human cerebral vasculature.

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Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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