Structure and Function of Hepatic Sinusoids

Endothelium Liver

The sinusoids are unique exchange vessels composed of specialized nonparenchymal cells that exhibit structural and functional heterogeneity. The structure of the sinusoid is illustrated in Figure 3. The endothelial cells are highly fenestrated and lack a supporting basal lamina. The fenestrae are organized in clusters known as sieve plates. As a result, there is continuity between the plasma in the sinusoid lumen and the perisinu-soidal space (of Disse). The sinusoidal endothelial cells contain...

Angiogenesis in Skin Diseases

Squamous cell carcinoma (SCC), a malignant tumor of keratinocytes with destructive growth pattern and the capacity to metastasize, arises as a result of exogenous carcinogens such as chronic exposure to sunlight, ionizing radiation, or chemicals. The stroma of SCC is richly vascu-larized and SCC tumor cells strongly express VEGF. Whereas the inhibition of VEGFR-2 (flk-1) prevents SCC growth and invasion, experimental overexpression of VEGF in highly differentiated SCC cell lines promotes...