Biocatalytic Scope of Baeyer Villiger Monooxygenases

Marco W. Fraaije and Dick B. Janssen

3.1 Introduction 77

3.1.1 The Baeyer-Villiger Reaction 77

3.1.2 Baeyer-Villiger Biocatalysts: Classification and Occurrence 78

3.1.2.1 Type I Baeyer-Villiger Monooxygenases 78

3.1.2.2 Type II Baeyer-Villiger Monooxygenases 78

3.1.2.3 Alternative Baeyer-Villiger Biocatalysts 79

3.2 Type I Baeyer-Villiger Monooxygenases: Versatile Oxidative Biocatalysts 80

3.2.1 Mechanistic and Structural Properties of Type I BVMOs 80

3.2.2 Diversity 84

3.2.3 Molecular Features 86

3.2.4 Kinetic Characteristics 86

3.2.5 Coenzyme Dependency 87

3.2.6 Uncoupling and Overoxidation 88

3.2.7 Biocatalyst Stability 88

3.2.8 Substrate Specificity 89

3.2.9 Unexplored Type I BVMOs 90

3.2.10 Mining Genomes for Novel BVMOs 92

3.3 Concluding Remarks 93 References 94

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