Other Alternatives

clindamycin (may substitute if sulfa allergic)

Daraprim 200mg PO load, then 50-75mg PO QD x 4-6 weeks

1-1.5gm PO or IV Q6hr x 4-6 weeks 10 mg PO QD x 4-6 weeks

300-600mg PO QID or 900mg IV QID x 4-6 weeks

Note: May consider concurrent treatment with oral prednisone (1 mg/kg/day) for inflammation

Trimethoprim/sulfamethoxazole Bactrim 10/50mg/kg/day PO divided BID

Single drug therapy with TMP/SMX was as effective as combination therapy with pyrimethamine and sulfadiazine in a prospective, randomized trial6

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