Specific Tests

The exceptions to the lack of "specific" markers of drug hepatotoxicity are the detection of liver-kidney microsomal type 2 (anti-P450 2C9) antibodies in tienilic acid-induced hepatitis, antimito-chondrial type 6 antibody in iproniazid-induced hepatitis (Homberg et al., 1985), and liver microsomal antibody (anti-P450 1A2) in dihydralazine-related liver injury (Bourdi et al., 1990). Both tienilic acid and iproniazid were withdrawn because of the high incidence of hepatotoxicity, and dihydralazine is rarely used now in clinical practice.

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