Drug-induced liver injury can cause any known pattern of liver pathology, although certain histological features are particularly suggestive of a drug-induced aetiology (Anon., 1974). Liver biopsy is also an important way to exclude alternative causes of a given pattern of liver injury. However, liver biopsy is an invasive procedure with significant morbidity in 0.24% and mortality in 0.11% of subjects (Cohen et al., 1992). Hence, benefits should be weighed against the risk and liver biopsy should be considered only in circumstances where discontinuation of the suspected medication is undesirable or when a patient appears to have an as yet unrecognised form of drug-induced liver injury.
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