trovafloxacin use (Public Health Advisory, 1999). In an effort better to characterize the contour and magnitude of risk over time, the survival technique was used. For comparison purposes, the background incidence rate for acute liver failure due to "idiopathic" causes was previously estimated at one case per million per year (Graham and Green, 1999). Based only on reported cases, the relative risk of acute liver failure was increased from the start of therapy and increased rapidly with increasing duration of exposure (Table 17.3).

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