For many years it has been known that a number of disorders are at particularly high risk of being drug-induced. Calls have been made to commence registries for such disorders, similar to the initiatives on aplastic anaemia following the chloramphenicol problem or the registry of vaginal adenocarcinoma in young women which proved so useful in identifying high dose stilboestrol in pregnancy as a culprit. These calls have yet to lead to action. It seems that this has been an opportunity missed. Perhaps someone will review the position in the near future, as I believe that a number of such registries could prove to be valuable additions to the pharmacovigilance arena as well as providing additional information about the natural history of the selected key disorders in the twenty-first century.
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