Diagnosis Of Adverse Hepatic Reaction

The importance of drugs as a cause of liver injury lies not in the overall number of cases, but in the severity of some reactions and their potential reversibility, provided the drug aetiology is promptly recognised. Adverse hepatic reactions can mimic a wide spectrum of hepatobiliary diseases. Early recognition and prompt withdrawal of the drug is essential in preventing serious hepatic failure and is the critical step in the management of adverse reactions (Nolan et al., 1999). Failure to detect hepatotoxicity at an early stage has led to mortality in many reported cases of hepatotoxicity (Moulding, 1999). The long-term prognosis of drug-induced hepatotoxicity may be worse if the responsible agent is continued (Aithal and Day, 1999).

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