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Rather than summarize what will be presented in a much more comprehensive book format in the near future, this chapter will review recent examples of approved prodrugs, their structures, the problem overcome, the rationale for the choice of promoiety, byproducts formed, and the enzymes likely responsible for the bioconversion. The emphasis will be on what "non-drugable" property was overcome via the prodrug modification. Table I provides much of this information in a table format.

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