Table of Contents

Introduction 102

Delivering Drug to the Test System 104

Drug Delivery for In vitro Screening Funnels 107

Drug Delivery for In vivo Screening 111

Enabling Formulation Strategies for Drug Delivery 114

Particle Size Reduction 115

High Energy Solids 116

Solubility Enhancement 117

Cosolvents 118

Ionization and pH Adjustment 119

Surfactants 121

Dispersed Lipid Phases 121

Complexation 122

Supersaturation 123

Conclusion 125

References 126

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