Table of Contents

Introduction 273

Defining ADR 273

Predicting patients versus predicting compounds 276

Imuunopathogenesis of immune-mediated idiosyncratic reactions 277

Characteristics of idiosyncratic toxins 282

Reactive intermediate formation 282

Covalent binding 284

Cytotoxicity 287

Other Characteristics 288 A working paradigm for lead optimization:

bioactivation, covalent binding, and cytotoxicity 288

References 293

0 0

Post a comment