Table of Contents

Overview 257

Bile Duct Hyperplasia 257

Interpretation of BDH for Drug Development 258

BDH Biomarker Identification 259

Identification of a candidate biomarker 259

Biomarker identity and confirmation of induction 262

DMBT1 protein induction and function 263

Biomarker Evaluation and Development 264

Specificity and sensitivity 264

Streamlining biomarker development 266

Summary 267

Acknowledgements 268

References 268

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