The No Nonsense Teds Fat Melting

The No Nonsense Teds Fat Melting

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Anderberg EK, Lindmark T, Artursson P. Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route. Pharm Res 1993; 10:857-864.

Batrakova EV, Han HY, Alakhov V, Miller DW, Kabanov AV. Effects of pluronic block copolymers on drug absorption in Caco-2 cell monolayers. Pharm Res 1998; 15:850-855.

Besnard P, Niot I, Poirier H, Clement L, Bernard A. New insights into the fatty acid-binding protein (FABP) family in the small intestine. Mol Cell Biochem 2002; 239:139-147.

Borgstrom B, Hildebrand H. Lipase and co-lipase activities of human small intestinal contents after a liquid test meal. Scand J Gastroenterol 1975; 10:585591.

Boyd M, Risovic V Jull P, Choo E, Wasan KM. A stepwise surgical procedure to investigate the lymphatic transport of lipid-based oral drug formulations: Cannulation of the mesenteric and thoracic lymph ducts within the rat. J

Pharmacol Toxicol Methods 2004; 49:115-120.

Caliph SM, Charman WN, Porter CJ. Effect of short-, medium-, and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats. J Pharm Sci 2000; 89:1073-1084.

Carey MC, Small DM, Bliss CM. Lipid digestion and absorption. Ann Rev Physiol 1983; 45:651-677.

Charman WN. Lipid vehicle and formulation effects on intestinal lymphatic drug transport. In: Charman WN, Stella VJ, eds. Lymphatic Transport of Drugs. Boca Raton: CRC Press, 1992:113-179

Charman WN, Noguchi T, Stella VJ. An experimental system designed to study the in situ intestinal lymphatic transport of drugs in anaesthetized rats. Int J Pharm 1986; 33:155-163.

Cornaire G, Woodley JF, Saivin S, Legendre JY, Decourt S, Cloarec A, Houin G. Effect of polyoxyl 35 castor oil and Polysorbate 80 on the intestinal absorption of digoxin in vitro. Arzneimittelforschung 2000; 50:576-579.

Cornaire G, Woodley J, Hermann P, Cloarec A, Arellano C, Houin G. Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo. Int J Pharm 2004; 278:119-131.

Edwards GA, Porter CJ, Caliph SM, Khoo SM, Charman WN. Animal models for the study of intestinal lymphatic drug transport. Adv Drug Deliv Rev 2001; 50:45-60.

Grimus R C and Schuster I. The role of the lymphatic transport in the enteral absorption of naftifine by the rat. Xenobiotica 1984; 14:287-297.

Hauss DJ, Mehta S, Radebaugh GW. Targeted lymphatic transport and modified systemic distribution of CI-976, a lipophilic lipid-regulator drug, via a formulation approach. Int J Pharm 1994; 108:85-93.

Hauss DJ, Fogal SE, Ficorilli JV Chronic collection of mesenteric lymph from conscious, tethered rats. Contemp Topics Lab Animal Sci 1998; 37:56-58.

Hernell O, Staggers JE, Carey MC. Physical-chemical behaviour of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings. Biochemistry 1990; 29:2041-2056.

Hoffman NE. The relationship between uptake in vitro of oleic acid and micellar solubilization. Biochim Biophys Acta 1970; 196:193-203.

Huang H, Starodub O, McIntosh A, Kier AB, Schroeder F. Liver fatty acid-binding protein targets fatty acids to the nucleus. Real time confocal and multiphoton fluorescence imaging in living cells. J Biol Chem 2002; 277:29139-29151.

Hugger ED, Novak BL, Burton PS, Audus KL, Borchardt RT. A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro. J Pharm Sci 2002; 91:1991-2002.

Humberstone AJ, Charman WN. Lipid based vehicles for the oral delivery of poorly water soluble drugs. Adv Drug Deliv Rev 1997; 25:103-128.

Hunt JN, Knox MT. A relation between the chain length of fatty acids and the slowing of gastric emptying. J Physiol (Lond) 1968; 194:327-336.

Ichihashi T, Kinoshita H, Takagishi Y and Yamada H. Effect of bile on absorption of mepitiostane by the lymphatic system in rats. J Pharm Pharmacol 1992a; 44:565-569.

Ichihashi T, Kinoshita H, Takagishi Y and Yamada H. Effect of oily vehicles on absorption of mepitiostane by the lymphatic system in rats. J Pharm Pharmacol 1992b; 44:560-564.

Kaukonen AM, Boyd BJ, Porter CJ, Charman WN. Drug solubilization behavior during in vitro digestion of simple triglyceride lipid solution formulations. Pharm Res 2004a; 21:245-253.

Kaukonen AM, Boyd BJ, Charman WN, Porter CJ. Drug solubilization behavior during in vitro digestion of suspension formulations of poorly water-soluble drugs in triglyceride lipids. Pharm Res 2004b; 21:254-260.

Khoo SM, Humberstone AJ, Porter CJH, Edwards GA, Charman WN. Formulation design and bioavailability assessment of lipidic self emulsifying formulations of halofantrine. Int J Pharm 1998; 167:155-164.

Khoo SM, Edwards GA, Porter CJ, Charman WN. A conscious dog model for assessing the absorption, enterocyte-based metabolism, and intestinal lymphatic transport of halofantrine. J Pharm Sci 2001; 90:1599-1607.

Khoo SM, Prankerd RJ, Edwards GA, Porter CJ and Charman WN. A physicochemical basis for the extensive intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after postprandial administration to dogs. J Pharm Sci 2002; 91:647-659

Khoo SM, Shackleford DM, Porter CJ, Edwards GA, Charman WN. Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs. Pharm Res 2003; 20:1460-1465.

Kuksis A. Absorption of fat soluble vitamins. In: Kuksis A. Fat Absorption. Boca Raton: CRC Press; 1987:65-86.

Ladas SD, Isaacs PE, Murphy GM, Sladen GE. Comparison of the effects of medium and long chain triglyceride containing liquid meals on gall bladder and small intestinal function in normal man. Gut 1984; 25:405-11.

Laher J M, Rigler M W, Vetter R D, Barrowman J A and Patton J S. Similar bioavailability and lymphatic transport of benzo(a)pyrene when administered to rats in different amounts of dietary fat. J Lipid Res 1984; 25:1337-1342.

Lindmark T, Nikkila T, Artursson P. Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial Caco-2 cell monolayers. J

Pharmacol Exp Ther 1995; 275:958-964.

Lindmark T, Schipper N, Lazorova L, de Boer AG, Artursson P. Absorption enhancement in intestinal epithelial Caco-2 monolayers by sodium caprate: assessment of molecular weight dependence and demonstration of transport routes. J Drug Target 1998; 5:215-223.

McArthur MJ, Atshaves BP, Frolov A, Foxworth WD, Kier AB, Schroeder F. Cellular uptake and intracellular trafficking of long chain fatty acids. J Lipid Res 1999; 40:1371-1383.

Nerurkar MM, Burton PS, Borchardt RT. The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system. Pharm Res 1996; 13:528-534.

Nerurkar MM, Ho NF, Burton PS, Vidmar TJ, Borchardt RT. Mechanistic roles of neutral surfactants on concurrent polarized and passive membrane transport of a model peptide in Caco-2 cells. J Pharm Sci 1997; 86:813-821.

Noguchi T, Charman WN, Stella VJ. Lymphatic appearance of DDT in thoracic or mesenteric lymph duct cannulated rats. Int J Pharm 1985; 24:185-192.

Nordskog BK, Phan CT, Nutting DF, Tso P. An examination of the factors affecting intestinal lymphatic transport of dietary lipids. Adv Drug Deliv Rev 2001; 50:2144.

Nutting DF, Kumar NS, St Hilaire RJ, Mansbach CM. Nutrient absorption. Curr Opin Clin Nutr Metab Care 1999; 2:413-419.

Ockner RK, Manning JA. Fatty acid-binding protein in small intestine. Identification, isolation, and evidence for its role in cellular fatty acid transport.

J Clin Invest 1974; 54:326-338.

O'Driscoll CM. Lipid-based formulations for intestinal lymphatic delivery. Eur J Pharm Sci 2002; 15:405-415

Palin KJ, Wilson CJ. The effect of different oils on the absorption of probucol in the rat. J. Pharm. Pharmacol. 1984; 36:641-643

Phan CT, Tso P. Intestinal lipid absorption and transport. Front Biosci 2001; 6:D299-319.

Poirier H, Degrace P, Niot I, Bernard A, Besnard P. Localization and regulation of the putative membrane fatty-acid transporter (FAT) in the small intestine. Comparison with fatty acid-binding proteins (FABP). Eur J Biochem 1996; 238:368-373.

Porter CJ, Charman WN. Lipid-based formulations for oral administration: opportunities for bioavailability enhancement and lipoprotein targeting of lipophilic drugs. J Recept Signal Transduct Res 2001a; 21:215-257.

Porter CJ, Charman WN. Intestinal lymphatic drug transport: an update. Adv

Drug Deliv Rev 2001b; 50:61-80.

Porter CJ, Charman WN. In vitro assessment of oral lipid based formulations. Adv Drug Deliv Rev 2001c; 50 Suppl 1:S127-47.

Porter CJH, Charman SA, Humberstone AJ, Charman WN. Lymphatic transport of halofantrine in the conscious rat when administered as either the free base or the hydrochloride salt: effect of lipid class and lipid vehicle dispersion. J Pharm Sci 1996a; 85:357-361.

Porter CJH, Charman SA, Charman WN. Lymphatic transport of halofantrine in the triple-cannulated anesthetized rat model: effect of lipid vehicle dispersion.

J Pharm Sci 1996b; 85:351-356.

Porter CJ, Edwards GA, Charman SA. Lymphatic transport of proteins after s.c. injection: implications of animal model selection. Adv Drug Deliv Rev 2001; 50:157-171.

Porter CJ, Kaukonen AM, Taillardat-Bertschinger A, Boyd BJ, O'Connor JM, Edwards GA, Charman WN. Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: studies with halofantrine. J Pharm Sci 2004a; 93:1110-1121.

Porter CJH, Kaukonen AM, Boyd BJ, Edwards GA, Charman WN. Susceptibility to lipase-mediated digestion reduces the oral bioavailability of danazol after oral administration as a medium-chain lipid based microemulsion formulation. Pharm Res 2004b; 21:1405-1412.

Pouton CW. Lipid formulations for oral administration of drugs: non-emulsifying, self emulsifying and 'self microemulsifying' drug delivery systems. Eur J Pharm Sci 2000; 11 Suppl. 2:S93-S98.

Reymond JP, Sucker H. In vitro model for ciclosporin intestinal absorption in lipid vehicles. Pharm Res 1988; 5:673-676.

Ros E. Intestinal absorption of triglyceride and cholesterol. Dietary and pharmacological inhibition to reduce cardiovascular risk. Atherosclerosis 2000; 151:357-379.

Schoeller C, Keelan M, Mulvey G, Stremmel W and Thomson AB. Oleic acid uptake into rat and rabbit jejunal brush border membrane. Biochim Biophys Acta 1995; 1236:51-64.

Sek L, Porter CJ, Kaukonen AM, Charman WN. Evaluation of the in-vitro digestion profiles of long and medium chain glycerides and the phase behaviour of their lipolytic products. J Pharm Pharmacol 2002; 54:29-41.

Shackleford DM, Faassen WA, Houwing N, Lass H, Edwards GA, Porter CJ, Charman WN. Contribution of lymphatically transported testosterone undecanoate to the systemic exposure of testosterone after oral administration of two andriol formulations in conscious lymph duct-cannulated dogs. J

Pharmacol Exp Ther 2003; 306:925-933.

Shackleford DM, Porter CJH, Charman WN. Lymphatic absorption of orally-administered prodrugs. In Prodrugs: Challenges and Rewards, Eds. V.J. Stella, R.T. Borchardt, M.J. Hageman, R. Oliyai, J.W. Tilley and H. Magg, AAPS Press, Washington DC, in press. 2004.

Shiau YF. Mechanism of intestinal fatty acid uptake in the rat: the role of an acidic microclimate. J Physiol 1990; 421:463-474.

Shono Y, Nishihara H, Matsuda Y, Furukawa S, Okada N, Fujita T, Yamamoto A. Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes. J Pharm Sci 2004; 93:877-885.

Sieber S M. The lymphocytic absorption of p,p'-DDT and some structurally-related compounds in the rat. Pharmacology 1976; 14:443-454

Simmonds WJ. The role of micellar solubilization in lipid absorption. Aust J Exp Biol Med Sci 1972; 50:403-421.

Staggers JE, Hernell O, Stafford R.J, Carey MC. Physical-chemical behaviour of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behaviour and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings. Biochemistry 1990; 29:2028-2040.

Stremmel W. Uptake of fatty acids by jejunal mucosal cells is mediated by a fatty acid binding membrane protein. J Clin Invest 1988; 82:2001-2010.

Stremmel W, Lotz G, Strohmeyer G, Berk PD. Identification isolation and partial characterization of a fatty acid binding protein from rat jejunal microvillus membranes. J Clin Invest 1985; 75:1068-1076.

Swartz MA. The physiology of the lymphatic system. Adv Drug Deliv Rev 2001; 50, 3-20.

Taillardat-Bertschinger A, Perry CS, Galland A, Prankerd RJ, Charman WN. Partitioning of halofantrine hydrochloride between water, micellar solutions and soybean oil: Effects on its apparent ionisation constant. J Pharm Sci 2003; 92, 2217-2228.

Thomson AB, Schoeller C, Keelan M, Smith L, Clandinin MT. Lipid absorption: passing through the unstirred layers, brush-border membrane, and beyond. Can

J Physiol Pharmacol 1993; 71:531-555.

Ueda C T, Lemaire M, Gsell G and Nussbaumer K. Intestinal lymphatic absorption of cyclosporin A following oral administration in an olive oil solution to rats. Biopharm Drug Dispos 1983; 4:113-120.

Wacher VJ, Wong S, Wong HT. Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole. J Pharm Sci 2002; 91:77-90.

Zangenberg NH, Mullertz A, Kristensen HG, Hovgaard L. A dynamic in vitro lipolysis model. I. Controlling the rate of lipolysis by continuous addition of calcium. Eur J Pharm Sci 2001a; 14:115-122.

Zangenberg NH, Mullertz A, Kristensen HG, Hovgaard L. A dynamic in vitro lipolysis model. II: Evaluation of the model. Eur J Pharm Sci 2001b; 14:237-244.

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