References

Di L and Kerns EH. Profiling drug-like properties in discovery research. Current Opinion in Chemical Biology 2003; 7: 402-408

Di L, Kerns EH, Fan K, McConnell OJ, Carter GT. High throughput artificial membrane permeability assay for blood-brain barrier. Eur. J. Med. Chem. 2003; 38: 223-232

Ellingboe JW, Cole DC, Nunn D, Gilbert AM, Stock J, Lennox W, Kelly MF, Lin M, Tischler M, Yaczko D, Sabus C. Library Design: Characterization of Building Block Sets by Principal Component Analysis. Gordon Research Conference on Combinatorial Chemistry, Oxford, UK, July 7-12, 2002

Ellingboe JW, Cole DC, Gilbert AM, Nunn D. The Application of Parallel Synthesis, High Throughput Pharmaceutical Profiling and Multivariate Analysis Tools to Lead Optimization. Advances in Synthetic, Combinatorial, and Medicinal Chemistry, Moscow, RU, May 5-8, 2004

Eriksson L, Johansson E, Kettaneh-Wold N, Wold S. Introduction to Multi- and Megavariate Data Analysis Using Projection Methods (PCA & PLS). Umea, Sweden: Umetrics AB; 1999. 490 p

Eriksson L, Johansson E, Kettaneh-Wold N, Wold S. Design of Experiments, Principles and Applications. Umea, Sweden: Umetrics AB; 2000. 320 p

Gilbert AM. Statistical Molecular Design and Multivariate Analysis of Acyl Carrier Protein Synthase (AcpS) Inhibitors. Gordon Research Conference on Combinatorial Chemistry, Tilton, NH, July 6-10, 2003

Gilbert AM. Physicochemical Compound Profiling/PLS Analysis: Tools to Optimize In Vitro/MIC Activity of Acyl-Carrier Protein Synthase (AcpS) Inhibitors. Drug Profiling Strategies: Compound-centric Approaches to Pharmaceutical Characterization and Prioritization Conference, Philadelphia, PA, June 29-30, 2004

Gilbert AM, Kirisits M, Toy P, Failli A, Dushin E, Novikova E, Petersen P, JosephMcCarthy DM, McFadyan I, Fritz CC. Anthranilate 4H-Oxazol-5-ones: Novel Small Molecule Antibacterial Acyl Carrier Protein Synthase (AcpS) Inhibitors. Bioorg. Med. Chem. Lett. 2004; 14: 37-41

Kansy M, Senner F, Gubernator K. Physicochemical High Throughput Screening: Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes. J. Med. Chem. 1998; 41:1007-1010

Kerns EH and Di L. Pharmaceutical profiling in drug discovery. Drug Discovery Today 2003; 8: 316-323

Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development setting. Adv. Drug Deliv. Rev. 1997; 23:3-25

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