List of Abbreviations

5-HT6 5-hydroxytryptamine-6 receptor

Acp acyl carrier protein

AcpS acyl carrier protein synthase

ADME absorption distribution metabolism excretion

BBB PAMPA blood brain barrier parallel artificial membrane permeability assay

COST changing one separate factor at a time

CYP cytochrome P450

DMSO dimethyl sulfoxide

DoE Design of Experiments

FAB fatty acid biosynthesis

MIC minimal inhibitory concentration

MVA multivariate data analysis

PAMPA parallel artificial membrane permeability assay

PCA principal component analysis

PLS projection to latent structures by means of a partial least squares analysis

R2X goodness of fit

Q2 goodness of prediction

SAR structure activity relationship

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