List of Abbreviations

2D6 Cytochrome P450 isozyme 2D6

BBB Blood brain barrier

BCEC Bovine conjunctival epithelial cells

BCSFB Blood CSF barrier

Caco-2 Human colon cancer cell line

CNS Central nerve system

CNS- Low CNS penetration

CNS+ High CNS penetration

CSF Cerebrospinal fluid

I.M Intra muscular

IC50 Concentration of an inhibitor at which 50% inhibition

Ki Inhibition constant

LC-MS Liquid Chromatography - Mass Spectroscopy

LC-MS-MS Liquid Chromatography - Tandem Mass Spectroscopy

LC-UV Liquid Chromatography-Ultraviolet spectroscopy

LLC-PKlRenal epithelial cell line originally derived from porcine kidneys

MAD Maximum Absorbable Dose

MC Methylcellulose

MDCK Madin - Darby Canine Kidney cell line

MDR1-MDCKII Multi drug resistant 1 - MDCKII cell line

Mpk Milligram per kilogram

MRP Multi-drug resistant proteins

PAMPA Parallel artificial membrane permeability assay

PAMPA-BBB Parallel artificial membrane permeability assay for BBB

PC Phosphatidyl Choline

Pe Effective permeability

PEG Polyethylene glycol

Pgp P-glycoprotein pKa Acidity constant

SGF Simulated gastro fluid

SIBLM Simulated bile salt lecithin mixture

SIF Simulated intestinal fluid

TM-BBB Transgenic mouse - BBB

TR-BBB Transgenic rat - BBB

UV Ultraviolet

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