ADME absorption distribution metabolism excretion

AUC area under the concentration-time curve

CAT compartmentalized absorption and transit

CYP cytochrome P450

Et extraction ratio fup fraction unbound in plasma

GFR glomerular filtration rate

NPSA non-polar surface area

PB -PK physiology-based pharmacokinetic

PK pharmacokinetic

PT:P blood to plasma partition coefficient

PSA polar surface area

Qt blood flow

RMSPE root mean squared prediction error

SPR structure-property relationships

Was this article helpful?

0 0

Post a comment