Summary

The design and development of inhalation drug delivery systems is a highly complex task. Optimization of the choice of compound polymorph and salt form is highly desirable, and an effective method of making small particles with consistent properties is essential. Adequate preformulation characterization of the chosen powder is essential. Formulation development should ideally be directed toward a specific objective predefined in terms of the system deployed for its clinical usefulness. Nebulizer solutions are perhaps the simplest formulations because the drug is water soluble. MDIs and DPIs require an understanding of both the chemical and physical attributes of the drug in relation to excipients, vehicles, and diluents and polymer components. However, common to the development of all systems is an appreciation that one of the most important factors in pulmonary delivery from an inhalation dosage form is the requirement for a good-quality aerosol (in terms of the aerodynamic particle size of cloud generated) and its potential to achieve the desired regional deposition in vivo.

Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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