Summary

The total and regional dose deposited in the lung, obtained using two- or three-dimensional scintigraphic imaging is a useful measurement of topical drug delivery, made doubly useful when correlated with pharmacodynamic and/or and pharmacokinetic data and preferably in the same subjects that undergo imaging. While the accuracy, sensitivity, and resolution of current 2D detectors is high, the use of 3D imaging is to be encouraged [28,45,52]. Further support for the deposition data must be provided by efficacy and safety studies of the test aerosol in various types of patients that would be prescribed the test medications. Knowledge of the lung dose and distribution of inhaled aerosols from delivery systems is critical for the assessment of their performance in vivo and can provide a rationale for adjusting the therapeutic dose for different categories of patients. Arguments for using imaging as a means of predicting clinical response have been raised [120,131]; however, improved accuracy of both in vitro and in vivo data must be demonstrated before this approach is accepted by the medical community as a suitable substitution for biological data.

Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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