The total and regional dose deposited in the lung, obtained using two- or three-dimensional scintigraphic imaging is a useful measurement of topical drug delivery, made doubly useful when correlated with pharmacodynamic and/or and pharmacokinetic data and preferably in the same subjects that undergo imaging. While the accuracy, sensitivity, and resolution of current 2D detectors is high, the use of 3D imaging is to be encouraged [28,45,52]. Further support for the deposition data must be provided by efficacy and safety studies of the test aerosol in various types of patients that would be prescribed the test medications. Knowledge of the lung dose and distribution of inhaled aerosols from delivery systems is critical for the assessment of their performance in vivo and can provide a rationale for adjusting the therapeutic dose for different categories of patients. Arguments for using imaging as a means of predicting clinical response have been raised [120,131]; however, improved accuracy of both in vitro and in vivo data must be demonstrated before this approach is accepted by the medical community as a suitable substitution for biological data.

Dealing With Asthma Naturally

Dealing With Asthma Naturally

Do You Suffer From ASTHMA Chronic asthma is a paralyzing, suffocating and socially isolating condition that can cause anxiety that can trigger even more attacks. Before you know it you are caught in a vicious cycle Put an end to the dependence on inhalers, buying expensive prescription drugs and avoidance of allergenic situations and animals. Get control of your life again and Deal With Asthma Naturally

Get My Free Ebook

Post a comment