Salts And Precipitates Salts

Surprisingly little work has been published since the early 1990s on the use of salt forms to enhance the performance of inhaled drugs. The concept is not novel and has not been ignored in years past [2-5]. Specific efforts were even made by Byron and coworkers in several publications [6-8] to demonstrate the influence of salt type on the dissolution of fluorescein in the lungs. Unfortunately, these observations appear not to have been exploited to a greater extent. Most of the work involving inhaled salts has revolved around inhalation toxicology of inorganic compounds found in the workplace or the environment. Perhaps this lack of pharmaceutical manipulation is a reflection of the de-emphasis of the pharmaceutical sciences within pharmacy curricula, in particular, those of the areas of physical chemistry [9], or, more simply, there have been numerous other avenues to pursue, which indeed there have. But surely the creation of drug salts is a less complex undertaking relative to creating dosage forms containing microspheres or liposomes, areas that have received far greater attention? Perhaps interest will be reinvigorated with the emergence of sensitive tools to analyze thermodynamic transformations, polymorphs, crystallites, and solvates of drugs [10-15]. Furthermore, the general recognition of the importance of surface characteristics [16] should ignite some enthusiasm toward altering these properties through manipulation of the salt.

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