Pharmacokinetics

The passage of a drug from the outlet of a nebulizer or metered-dose inhaler to its therapeutic or biological site of action is governed by many factors, which may be grouped empirically into two categories: (1) physical factors, which determine the deposition of drug from the mouth and onto the surface of the airway lumen, and (2) pharmacokinetic factors, which influence the amount of drug passing from the airway lumen to the target cell or tissue, i.e., the site at which the drug acts in producing a therapeutic action.

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