Particle Deposition

The site and quantity of particle deposition in the respiratory tract depend mainly on particle size but are also affected by respiratory pattern and airway pathology. Understanding the terminology of particle deposition is essential. Deposition is the capture of particles on a surface. Some inhaled particles are deposited by the respiratory epithelium, and others are exhaled. Clearance is the removal of any deposited particles by any process and is not a major topic of this discussion, although it may be important for the efficacy of inhaled medications. Total deposition is the difference between the inhaled and exhaled mass of the substance of interest. Regional deposition defines mass in various anatomic levels in the respiratory tract [5]. Regions are defined as (1) the nasopharyngeal region, which is from the nose to the vocal cords, (2) the tracheobronchial region (tracheobronchial), from the vocal cords to and including terminal bronchioles (generations 0-17), and pulmonary region (pulmonary), from and including respiratory bronchioles to distal alveoli [5]. Throughout this chapter, these abbreviations are used to refer to these regions. Note that the Task Group model is a nasal inhalation model and is not representative of mouth inhalation. For some aspects of discussion, the tracheobronchial region may be considered in two parts, large airways (trachea through subsegmental airways) and small airways (generations 6-17). Deposition can also be considered on the basis of deposition per airway generation and deposition per unit surface area.

Surface Area Concentration

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Diabetes 2

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