Measurement of Deposition

If targeting is a goal, it must be based on a presumption that deposition can in some way be assessed to determine the outcome of targeting. Assessment of pharmacokinetic and pharmacodynamic effects is useful. Direct quantitative measurement of targeting, i.e., the measurement of deposition by airway generation, is generally not possible in human beings. A recent study of deposition of a stable isotope of triamcinolone is remarkable in the accomplishment because it accomplishes separation of deposition between conducting airways and acinar airways, i.e., generations 1-14 and 15-23, using PET scanning [16]. This technique is of great interest and has considerable research potential. Comparison of such measurements to changes in outcome measured by clinical parameters would add a new dimension in the assessment of therapeutic aerosol design.

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