Lipoxygenase Inhibitors

An interesting correlation between pseudoperoxidase activity and 5-lipoxygenase inhibitory potency has been observed for a series of N-hydroxy ureas, suggesting that the redox properties of this class of drug contribute to their ability to inhibit 5-lipoxygenase [92]. Some compounds has been investigated; the Zileuton (A-64,077) (35) shows activity in humans [96]. A series of quinoline-containing inhibitors of LT biosynthesis—WY-49,232 (36), L-674,573 (37), and REV-5,901 (38)—have been found to bind to the 5-lipoxygenose-activating protein (FLAP); their ability to interact with FLAP correlated well with inhibition of LT biosynthesis.

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