Inhalation Drug Delivery System Designmetereddose Inhalers Introduction

A metered-dose inhaler (MDI) is a complex system designed to provide a fine mist of medicament, generally with an aerodynamic particle size of less than 5 microns, for inhalation directly to the airways for the treatment of respiratory diseases such as asthma and COPD.

The main components of all MDIs (Fig. 4) are:

• The active ingredient

• The propellant (a liquefied gas)

• A metering valve

• An actuator/mouthpiece

The active ingredient (the drug) may be either dissolved in the propellant or a cosolvent (e.g., ethanol) or suspended in the propellant. A surface-active agent

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