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Figure 10 Possible absorption profiles obtained from experiments with isolated perfused lung or absorption profiles obtained after proper deconvolution from inhalation studies. Lines present drugs with different absorption rates. Circles = fast, squares = intermediate, and hexagons = slow absorption rates.

coworkers [63] employed an in vitro approach using the isolated perfused lung as a tool for a detailed assessment of the pulmonary fate of fluorescent-labeled analytes, absorbed by carrier-mediated or passive absorption, or removed by the mucociliary escalator. The method was able to generate data on the rate of mucociliary transport of the formulation. Applying this method to other drugs might allow a detailed assessment of the pulmonary pharmacokinetics, including mucociliary removal.

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