Info

membrane

Carbonic anhydrase

Endothelial membrane

ATPase (EC 3.6.1.8)

Endothelial membrane

ADPase (EC 3.6.1.5)

Endothelial membrane

Source: Ref. 149.

Source: Ref. 149.

In order to achieve the desired pharmacological effects without unwanted side effects it is likely that selective targeting of specific enzymes will be necessary. Selective inhibition of a specific target enzyme has recently been achieved using Rolipram (52) a selective PDE IV inhibitor, which shows reduction in allergen-induced bronchiol hyperreactivity in guinea pigs dosed at 75 mg/kg i.p. [145].

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