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The clinical use of LTD4 antagonists is being enthusiastically pursued, although no definitive clinical evidence has been presented that supports a role for the peptide LTs in asthma and allergy. With respect to aerosolized drug studies, SKF 104353-22 (33) has been shown to block LTD4- and antigen-induced bronchoconstriction in asthmatics on aerosol administration [93,94]. L-648051 (34) represents another aerosol-administered antagonist that has reached the clinic. Relatively large doses (~ 12 mg) are required to inhibit LTD4 bronchoconstriction [95].

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