The role of thermoboxane antagonists is asthma treatment still remains uncertain. AA-2414 (41) oral administration to asthmatic subjects favorably attenuated their response to methacholine challenge . Modification of a 7-oxabicyclo heptane of drug candidates by incorporation of a phenylene spacer in the a-chain afforded SQ 35,091 (42), which shows longer duration of action (t1/2 = 16hr) . GR 32191 (43) shows PGD2-induced bronchoconstriction in asthmatics at 80 mg PO .
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