Imaging Studies

In vivo radiographic imaging techniques are proving to be extremely useful in assessing drug deposition [66,67]. These methods include gamma scinitigraphy (e.g., gamma-emitting nuclide 99mTc), single-photon emission tomography (SPECT), positron emission tomography (PET), and, for limited applications, magnetic resonance imaging, which does not require radioactive labeling. These techniques, as discussed in more detail in other chapters of this book, are able to provide detailed information on the degree and location of pulmonary deposition. In addition, pulmonary pharmacokinetics can be assessed if the drug particles are labeled and can be followed over an extended period of time [68].

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