Although the dependence of the aerodynamic diameter on particle density is relatively weak, recent advances in particle engineering produced pharmaceu-tically interesting porous particles [105]. The geometric diameters of these porous particles are several times greater than the aerodynamic diameters, because the density of the porous material is much lower than that of water. Of course, it is expected that the deposition of these particles will be governed by their aerodynamic, rather than geometric, size. These particles are also claimed to be more resistant to phagocytosis by alveolar macrophages and could therefore provide increased duration of action in the alveolar regions ("temporal" or "kinetic" targeting—see later).

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