Contents

Foreword Charles G. Thiel

Foreword to the First Edition John J. Sciarra

Preface

Contributors

Part One: FACTORS GOVERNING AEROSOL DEPOSITION AND TARGETING IN THE LUNG

1. Physiology of the Airways

Anthony J. Hickey and David C. Thompson

2. Pharmacology of Therapeutic Aerosols David C. Thompson

3. Targeting by Deposition Igor Gonda

4. Drug Targeting to the Lung: Chemical and Biochemical Considerations

Peter A. Crooks and Abeer M. Al-Ghananeem

5. Lung Deposition Simulation W. H. Finlay

6. Practical Aspects of Imaging Techniques Employed to Study Aerosol Deposition and Clearance

Myrna B. Dolovich

7. Pharmacokinetics and Pharmacodynamics of Drugs Delivered to the Lungs

Manish Issar, Cary Mobley, Patricia Khan, and G√ľnther Hochhaus

Part Two: METHODS OF GENERATION, ADMINISTRATION, AND CHARACTERIZATION OF AEROSOLS

8. Theoretical Principles and Devices Used to Generate Aerosols for Research

Keng H. Leong

9. The Design and Development of Inhalation Drug Delivery Systems

Paul J. Atkins and Timothy M. Crowder

10. Aerosol-Filling Equipment for the Preparation of Pressurized-Pack Pharmaceutical Formulations Christophe Sirand, Jean-Pierre Varlet, and Anthony J. Hickey

11. Methods of Aerosol Particle Size Characterization Anthony J. Hickey

12. Summary of Common Approaches to Pharmaceutical Aerosol Administration

Anthony J. Hickey

Part Three: CLINICAL ASPECTS OF AEROSOL ADMINISTRATION AND FUTURE PERSPECTIVES

13. Therapeutic Aerosols: An Overview from a Clinical Perspective F. Charles Hiller

14. Aerosolized Pentamidine for Treatment and Prophylaxis of Pneumocystis carinii Pneumonia in Patients with Acquired Immunodeficiency Syndrome

Anthony J. Hickey and A. Bruce Montgomery

15. The Application of Aerosolized Antimicrobial Therapies in Lung Infections

Dennis M. Williams

16. Gene Delivery to the Lung

Justin Hanes, Michelle Dawson, Yah-el Har-el, Junghae Suh, and Jennifer Fiegel

17. Recent Advances Related to the Systemic Delivery of Therapeutic Molecules by Inhalation

David A. Edwards, Andre X. Valente, Jonathan Man, and Nicolas Tsapis

18. Modulated Drug Therapy with Inhalation Aerosols: Revisited Ralph Niven

19. Pulmonary Delivery Technology: Recent Advances and Potential for the New Millennium

Andrew R. Clark

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