Conclusions

The concluding remarks made in the first edition of the book highlighted numerous opportunities that were not being realized due to general concerns about safety. Unfortunately, despite the greater awareness of the inhaled route as a mode of delivery, the landscape is still essentially the same. One could also argue that there has not been a compelling economic reason to tackle the safety and formulation questions, which, although difficult, are not insurmountable. Despite this sobering viewpoint and the critical nature of this discourse, there is a promising trend within the field. Efforts under way appear more focused and, rather than emphasizing feasibility, tend to be more product oriented. That is, the choices of drug and components are being made on a rational pharmaceutical basis. Hopefully, this trend will continue and the inherent risks of pursuing modulated pulmonary drug delivery will be rewarded.

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