B

Cone Spacer

Figure 20 (A) Schematic and (B) photograph of cone spacer (Inhal-Aid).

device using a b-receptor agonist. Studies performed using spacers have focused initially on the advantage of their combination with an MDI rather than on the use of an MDI alone [214-217]. Beyond this, the comparison of jet nebulizers with the combination MDI and spacer system has been performed [206,211,212], with conflicting conclusions. Finally, the impact of the MDI and spacer system on therapy with different drugs has been considered [207].

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