Aerosolized Pentamidine Therapy For Active Pneumocystis Carinii Pneumonia

The overall rate of PCP prophylaxis failure has decreased significantly since 1995, coincident with the era of highly active antiretroviral therapy (HAART) [20].

Four pilot and three controlled studies using aerosolized pentamidine were conducted (Tables 1 and 2) [17,18,21-23]. Montgomery et al. [18] studied one group of AIDS patients with PCP who had received no prior therapy [18] and a second group that was intolerant to standard therapy [22]. Of the 25 patients, 23 recovered. Relapses occurred in only three patients during a mean follow-up of more than 1 year. No adverse systemic reactions were observed with aerosolized

Table 1 Aerosolized Pentamidine Studies for Mild-to-Moderate PCP in Patients with AIDS

Study group


Nebulizer type

ADR requiring drug change




First episode

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