Aerosolized Pentamidine Therapy For Active Pneumocystis Carinii Pneumonia

The overall rate of PCP prophylaxis failure has decreased significantly since 1995, coincident with the era of highly active antiretroviral therapy (HAART) [20].

Four pilot and three controlled studies using aerosolized pentamidine were conducted (Tables 1 and 2) [17,18,21-23]. Montgomery et al. [18] studied one group of AIDS patients with PCP who had received no prior therapy [18] and a second group that was intolerant to standard therapy [22]. Of the 25 patients, 23 recovered. Relapses occurred in only three patients during a mean follow-up of more than 1 year. No adverse systemic reactions were observed with aerosolized

Table 1 Aerosolized Pentamidine Studies for Mild-to-Moderate PCP in Patients with AIDS

Study group

n

Nebulizer type

ADR requiring drug change

(%)

(%)

Ref.

First episode

Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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