Aerosol Particle Size

The influence of particle size on the deposition pattern of a drug in the lung is summarized as follows [2]:

Selection of an appropriate monodisperse (i.e., uniform particle size) aerosol may permit the administration of a drug to the central or peripheral airways, a process that may be of benefit in targeting drugs for local or systemic actions. In general, however, aerosols used in therapy are polydisperse (i.e., consist of a range of particle sizes) and, therefore, distribute throughout the airways. Nevertheless, it should be recognized that 10% or less of an administered aerosol dose will attain the airways, with the remainder depositing on the mouth or pharynx or being swallowed [3].

Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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