Aerosol Particle Size

The influence of particle size on the deposition pattern of a drug in the lung is summarized as follows [2]:

Selection of an appropriate monodisperse (i.e., uniform particle size) aerosol may permit the administration of a drug to the central or peripheral airways, a process that may be of benefit in targeting drugs for local or systemic actions. In general, however, aerosols used in therapy are polydisperse (i.e., consist of a range of particle sizes) and, therefore, distribute throughout the airways. Nevertheless, it should be recognized that 10% or less of an administered aerosol dose will attain the airways, with the remainder depositing on the mouth or pharynx or being swallowed [3].

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