Fig. 5-9. A, Effects of digoxin on survival after encephalomyocarditis (EMC) virus inoculation. Survival decreased in a dose-dependent manner. Treatment with digoxin, 10 mg/kg per day, significantly increased the 14-day mortality (P < 0.0001 vs. control). B, Effect of digoxin on myocardial interleukin (ZL)-1ß, IL-6, and tumor necrosis factor (TNF)-a production measured on day 5 after EMC virus inoculation. In the animals treated with digoxin, 1 mg/kg, IL-1ß was significantly higher than in the control group. **P < 0.01. Intracardiac TNF-a levels increased in a dose-dependent manner. *P < 0.05 and ***P < 0.001. (From Matsumori et al. 84 By permission of the Japanese Circulation Society.)
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