Chemotherapy Induced Nausea Dexamethasone

10 mg/m2/dose (max 20 mg) IV x 1, then 5 mg/m2/dose (max 10 mg) IV q6h prn [inj: 4 mg/mL, 10 mg/mL] -Dronabinol (Marinol) 5 mg/m2/dose PO 1-3 hrs prior to chemotherapy, then q4h prn afterwards. May titrate up in 2.5 mg/m2/dose increments to max of 15 mg/m2/dose. [cap: 2.5, 5, 10 mg] -Granisetron (Kytril)

10-20 mcg/kg IV given just prior to chemotherapy (single dose) [inj: 1 mg/mL]

Adults (oral) 1 mg PO bid or 2 mg PO qd [tab: 1 mg] -Metoclopramide (Reglan) 0.5-1 mg/kg/dose IV q6h prn. Pretreatment with diphenhydramine 1 mg/kg IV is recommended to decrease the risk of extrapyramidal reactions. [inj: 5 mg/mL] -Ondansetron (Zofran) 0.15 mg/kg/dose IV 30 minutes before chemotherapy and repeated 4 hr and 8 hr later (total of 3 doses) OR 0.3 mg/kg/dose IV x 1 30 minutes before chemotherapy OR

0.45 mg/kg/day as a continuous IV infusion OR

Oral:

<0.3 m2: 1 mg PO three times daily

0.3-0.6 m2: 2 mg PO three times daily

0.6-1 m2: 3 mg PO three times daily

>1 m2: 4 mg PO three times daily OR

4-11 year: 4 mg PO three times daily

>11 year: 8 mg PO three times daily

[inj: 2 mg/mL; oral soln: 4mg/5 mL; tab: 4, 8, 24 mg;

tab, orally disintegrating: 4, 8 mg]

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