Composition

A commercially prepared fibrin sealant comes in a kit that includes two lyophilized components. One component contains a pooled fibrinogen factor XIII concentrate, which is dissolved in an antifibrinolytic solution (aprotinin). The other component is bovine thrombin reconstituted with 40 mM CaCl2. The kit also includes a double-barreled syringe system that releases equal volumes of fibrinogen and thrombin through a needle. Historically, the main problem with fibrin sealants was the high associated risk of hepatitis transmission from the human plasma pooled to obtain fibrinogen. The composition of commercial solutions varies considerably. The fibrinogen concentration ranges between 50 and 115 mg/mL, whereas that of factor XIII is 5-80 IU/mL. The thrombin concentration ranges from 200 to 600 u/mL2.

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