Special Populations

No adjustment in the dosage of either pioglitazone or rosiglitazone is required in renal insufficiency or in elderly populations [27,67]. However, there are now few reports of congestive heart failure caused or exacerbated by thiazolidinediones in the setting of chronic renal insufficiency [73], which suggests that in patients with renal insufficiency, a lower dose of a thiazolidinedione may be safer to use. Neither drug should be used in patients who have serum hepatic transaminase levels greater than 2.5 times the upper limit of normal (see adverse effects). Both agents are classified as pregnancy category C and should be avoided in pregnant women. It is not known whether either drug is excreted in breast milk. There are insufficient data supporting the use of either drug in pediatric populations [27,67].

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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