Pharmacological Interventions Aimed at Decreasing CVD Risk

Theoretically, if insulin sensitivity is enhanced in insulin-resistant persons, the associated improvement in CVD risk factors should lead to a decrease in CVD. Although there is substantive evidence that weight loss and treatment with TZD compounds will improve insulin sensitivity in insulin-resistant individuals, associated with an improved CVD risk profile, there are no clinical trials that provide experimental evidence that either approach will decrease CVD events. In the absence of such information, it is necessary to consider the potential clinical utility of addressing specific CVD risk factors, associated with the IRS, in an effort to decrease CVD. In the next section, therapeutic approaches to two such factors - dyslipidemia and hypertension - will be considered.

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