We have used several approaches to investigate the regulation of DENV translation and replication, which are summarized below. One set of studies identified a coding region RNA structure that determines translational start site selection and plays a distinct, essential role in viral replication. In another investigation, mor-pholino oligomers targeting conserved domains in the 5' and 3' UTRs were used to dissect the roles of these domains in DENV translation and RNA synthesis. Finally, the mechanism of DENV translation initiation was investigated and found to proceed via both a canonical cap-dependent as well as a non-canonical mechanism.
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