T

Thyroid hormones figure 50-10

The thyroid hormones regulate cellular metabolic rates through several negative feedback mechanisms. Two are shown. High concentrations of thyroid hormones inhibit the hypothalamus from releasing TRH and the anterior pituitary from releasing TSH.

figure 50-11

In negative feedback, a secondary substance (A) inhibits production of the initial stimulating substance (B). In positive feedback, a secondary substance (A) stimulates production of the initial stimulating substance (B).

Negative Feedback

Time

Positive Feedback

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